That's one of the key questions facing U.S. government agencies and corporations as they scramble to deploy next-generation Internet technology ahead of the fast-approaching exhaustion of IP addresses using the current standard, known as IPv4.
The University of New Hampshire InterOperability Laboratory's (UNH-IOL) hosted a plugfest for Transparent Interconnection of Lots of Links (TRILL) from August 3rd-5th, 2010. This white paper from the event discusses the results of the plugfest.